Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.
Identifieur interne : 000564 ( Main/Exploration ); précédent : 000563; suivant : 000565Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.
Auteurs : Javier Trigo [Espagne] ; David García-Azorín [Espagne] ; Álvaro Planchuelo-G Mez [Espagne] ; Enrique Martínez-Pías [Espagne] ; Blanca Talavera [Espagne] ; Isabel Hernández-Pérez [Espagne] ; Gonzalo Valle-Pe Acoba [Espagne] ; Paula Sim N-Campo [Espagne] ; Mercedes De Lera [Espagne] ; Alba Chavarría-Miranda [Espagne] ; Cristina L Pez-Sanz [Espagne] ; María Gutiérrez-Sánchez [Espagne] ; Elena Martínez-Velasco [Espagne] ; María Pedraza [Espagne] ; Álvaro Sierra [Espagne] ; Beatriz G Mez-Vicente [Espagne] ; Juan Francisco Arenillas [Espagne] ; Ángel L. Guerrero [Espagne]Source :
- The journal of headache and pain [ 1129-2377 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Céphalée (mortalité), Céphalée (épidémiologie), Céphalée (étiologie), Femelle (MeSH), Hospitalisation (MeSH), Humains (MeSH), Infections à coronavirus (complications), Infections à coronavirus (mortalité), Infections à coronavirus (épidémiologie), Mortalité hospitalière (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (mortalité), Pneumopathie virale (épidémiologie), Pronostic (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Taux de survie (MeSH), Études rétrospectives (MeSH).
- MESH :
- mortalité : Céphalée, Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Céphalée, Infections à coronavirus, Pneumopathie virale.
- étiologie : Céphalée.
- complications : Adulte d'âge moyen, Betacoronavirus, Femelle, Hospitalisation, Humains, Infections à coronavirus, Mortalité hospitalière, Mâle, Pandémies, Pneumopathie virale, Pronostic, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Études rétrospectives.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (complications), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Female (MeSH), Headache (epidemiology), Headache (etiology), Headache (mortality), Hospital Mortality (MeSH), Hospitalization (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Prognosis (MeSH), Retrospective Studies (MeSH), Survival Rate (MeSH).
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Headache, Pneumonia, Viral.
- etiology : Headache.
- mortality : Coronavirus Infections, Headache, Pneumonia, Viral.
- Aged, Aged, 80 and over, Betacoronavirus, Female, Hospital Mortality, Hospitalization, Humans, Male, Middle Aged, Pandemics, Prognosis, Retrospective Studies, Survival Rate.
Abstract
INTRODUCTION
Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.
METHODS
Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis.
RESULTS
During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer.
CONCLUSION
Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.
DOI: 10.1186/s10194-020-01165-8
PubMed: 32727345
PubMed Central: PMC7388434
Affiliations:
Links toward previous steps (curation, corpus...)
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Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Perez, Isabel" sort="Hernandez Perez, Isabel" uniqKey="Hernandez Perez I" first="Isabel" last="Hernández-Pérez">Isabel Hernández-Pérez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Valle Pe Acoba, Gonzalo" sort="Valle Pe Acoba, Gonzalo" uniqKey="Valle Pe Acoba G" first="Gonzalo" last="Valle-Pe Acoba">Gonzalo Valle-Pe Acoba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Sim N Campo, Paula" sort="Sim N Campo, Paula" uniqKey="Sim N Campo P" first="Paula" last="Sim N-Campo">Paula Sim N-Campo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="De Lera, Mercedes" sort="De Lera, Mercedes" uniqKey="De Lera M" first="Mercedes" last="De Lera">Mercedes De Lera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Chavarria Miranda, Alba" sort="Chavarria Miranda, Alba" uniqKey="Chavarria Miranda A" first="Alba" last="Chavarría-Miranda">Alba Chavarría-Miranda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Sanz, Cristina" sort="L Pez Sanz, Cristina" uniqKey="L Pez Sanz C" first="Cristina" last="L Pez-Sanz">Cristina L Pez-Sanz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Gutierrez Sanchez, Maria" sort="Gutierrez Sanchez, Maria" uniqKey="Gutierrez Sanchez M" first="María" last="Gutiérrez-Sánchez">María Gutiérrez-Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Martinez Velasco, Elena" sort="Martinez Velasco, Elena" uniqKey="Martinez Velasco E" first="Elena" last="Martínez-Velasco">Elena Martínez-Velasco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Pedraza, Maria" sort="Pedraza, Maria" uniqKey="Pedraza M" first="María" last="Pedraza">María Pedraza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Sierra, Alvaro" sort="Sierra, Alvaro" uniqKey="Sierra A" first="Álvaro" last="Sierra">Álvaro Sierra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="G Mez Vicente, Beatriz" sort="G Mez Vicente, Beatriz" uniqKey="G Mez Vicente B" first="Beatriz" last="G Mez-Vicente">Beatriz G Mez-Vicente</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Arenillas, Juan Francisco" sort="Arenillas, Juan Francisco" uniqKey="Arenillas J" first="Juan Francisco" last="Arenillas">Juan Francisco Arenillas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Valladolid, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valladolid, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Neurovascular Research Laboratory. Instituto de Biología y Genética Molecular, Universidad de Valladolid - Consejo Superior de Investigaciones Científicas, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurovascular Research Laboratory. Instituto de Biología y Genética Molecular, Universidad de Valladolid - Consejo Superior de Investigaciones Científicas, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Guerrero, Angel L" sort="Guerrero, Angel L" uniqKey="Guerrero A" first="Ángel L" last="Guerrero">Ángel L. Guerrero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Valladolid, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valladolid, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32727345</idno><idno type="pmid">32727345</idno><idno type="doi">10.1186/s10194-020-01165-8</idno><idno type="pmc">PMC7388434</idno><idno type="wicri:Area/Main/Corpus">000938</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000938</idno><idno type="wicri:Area/Main/Curation">000938</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000938</idno><idno type="wicri:Area/Main/Exploration">000938</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.</title><author><name sortKey="Trigo, Javier" sort="Trigo, Javier" uniqKey="Trigo J" first="Javier" last="Trigo">Javier Trigo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Azorin, David" sort="Garcia Azorin, David" uniqKey="Garcia Azorin D" first="David" last="García-Azorín">David García-Azorín</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain. davilink@hotmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Planchuelo G Mez, Alvaro" sort="Planchuelo G Mez, Alvaro" uniqKey="Planchuelo G Mez A" first="Álvaro" last="Planchuelo-G Mez">Álvaro Planchuelo-G Mez</name><affiliation wicri:level="1"><nlm:affiliation>Imaging Processing Laboratory, Universidad de Valladolid, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Imaging Processing Laboratory, Universidad de Valladolid, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Martinez Pias, Enrique" sort="Martinez Pias, Enrique" uniqKey="Martinez Pias E" first="Enrique" last="Martínez-Pías">Enrique Martínez-Pías</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Talavera, Blanca" sort="Talavera, Blanca" uniqKey="Talavera B" first="Blanca" last="Talavera">Blanca Talavera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Perez, Isabel" sort="Hernandez Perez, Isabel" uniqKey="Hernandez Perez I" first="Isabel" last="Hernández-Pérez">Isabel Hernández-Pérez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Valle Pe Acoba, Gonzalo" sort="Valle Pe Acoba, Gonzalo" uniqKey="Valle Pe Acoba G" first="Gonzalo" last="Valle-Pe Acoba">Gonzalo Valle-Pe Acoba</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Sim N Campo, Paula" sort="Sim N Campo, Paula" uniqKey="Sim N Campo P" first="Paula" last="Sim N-Campo">Paula Sim N-Campo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="De Lera, Mercedes" sort="De Lera, Mercedes" uniqKey="De Lera M" first="Mercedes" last="De Lera">Mercedes De Lera</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Chavarria Miranda, Alba" sort="Chavarria Miranda, Alba" uniqKey="Chavarria Miranda A" first="Alba" last="Chavarría-Miranda">Alba Chavarría-Miranda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Sanz, Cristina" sort="L Pez Sanz, Cristina" uniqKey="L Pez Sanz C" first="Cristina" last="L Pez-Sanz">Cristina L Pez-Sanz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Gutierrez Sanchez, Maria" sort="Gutierrez Sanchez, Maria" uniqKey="Gutierrez Sanchez M" first="María" last="Gutiérrez-Sánchez">María Gutiérrez-Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Martinez Velasco, Elena" sort="Martinez Velasco, Elena" uniqKey="Martinez Velasco E" first="Elena" last="Martínez-Velasco">Elena Martínez-Velasco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Pedraza, Maria" sort="Pedraza, Maria" uniqKey="Pedraza M" first="María" last="Pedraza">María Pedraza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Sierra, Alvaro" sort="Sierra, Alvaro" uniqKey="Sierra A" first="Álvaro" last="Sierra">Álvaro Sierra</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="G Mez Vicente, Beatriz" sort="G Mez Vicente, Beatriz" uniqKey="G Mez Vicente B" first="Beatriz" last="G Mez-Vicente">Beatriz G Mez-Vicente</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Arenillas, Juan Francisco" sort="Arenillas, Juan Francisco" uniqKey="Arenillas J" first="Juan Francisco" last="Arenillas">Juan Francisco Arenillas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Valladolid, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valladolid, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Neurovascular Research Laboratory. Instituto de Biología y Genética Molecular, Universidad de Valladolid - Consejo Superior de Investigaciones Científicas, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurovascular Research Laboratory. Instituto de Biología y Genética Molecular, Universidad de Valladolid - Consejo Superior de Investigaciones Científicas, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Guerrero, Angel L" sort="Guerrero, Angel L" uniqKey="Guerrero A" first="Ángel L" last="Guerrero">Ángel L. Guerrero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Valladolid, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, University of Valladolid, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author></analytic><series><title level="j">The journal of headache and pain</title><idno type="eISSN">1129-2377</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Female (MeSH)</term><term>Headache (epidemiology)</term><term>Headache (etiology)</term><term>Headache (mortality)</term><term>Hospital Mortality (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Prognosis (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Survival Rate (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Céphalée (mortalité)</term><term>Céphalée (épidémiologie)</term><term>Céphalée (étiologie)</term><term>Femelle (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mortalité hospitalière (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (épidémiologie)</term><term>Pronostic (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Taux de survie (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Headache</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Headache</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Headache</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Céphalée</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Céphalée</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Céphalée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>Female</term><term>Hospital Mortality</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prognosis</term><term>Retrospective Studies</term><term>Survival Rate</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Infections à coronavirus</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Pronostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32727345</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>10</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1129-2377</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>29</Day></PubDate></JournalIssue><Title>The journal of headache and pain</Title><ISOAbbreviation>J Headache Pain</ISOAbbreviation></Journal><ArticleTitle>Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study.</ArticleTitle><Pagination><MedlinePgn>94</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s10194-020-01165-8</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Trigo</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Azorín</LastName><ForeName>David</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3132-1064</Identifier><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain. davilink@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Planchuelo-Gómez</LastName><ForeName>Álvaro</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Imaging Processing Laboratory, Universidad de Valladolid, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Pías</LastName><ForeName>Enrique</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Talavera</LastName><ForeName>Blanca</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández-Pérez</LastName><ForeName>Isabel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valle-Peñacoba</LastName><ForeName>Gonzalo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simón-Campo</LastName><ForeName>Paula</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Lera</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chavarría-Miranda</LastName><ForeName>Alba</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Sanz</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gutiérrez-Sánchez</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Velasco</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pedraza</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sierra</LastName><ForeName>Álvaro</ForeName><Initials>Á</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gómez-Vicente</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arenillas</LastName><ForeName>Juan Francisco</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Valladolid, Valladolid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neurovascular Research Laboratory. Instituto de Biología y Genética Molecular, Universidad de Valladolid - Consejo Superior de Investigaciones Científicas, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerrero</LastName><ForeName>Ángel L</ForeName><Initials>ÁL</Initials><AffiliationInfo><Affiliation>Department of Neurology, Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal 3, 47003, Valladolid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Valladolid, Valladolid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Headache Pain</MedlineTA><NlmUniqueID>100940562</NlmUniqueID><ISSNLinking>1129-2369</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006261" MajorTopicYN="N">Headache</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="Y">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Headache disorders, secondary</Keyword><Keyword MajorTopicYN="N">Mortality, laboratory parameters</Keyword><Keyword MajorTopicYN="N">Nervous system diseases</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32727345</ArticleId><ArticleId IdType="doi">10.1186/s10194-020-01165-8</ArticleId><ArticleId IdType="pii">10.1186/s10194-020-01165-8</ArticleId><ArticleId 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